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Above the researchers designed a novel graft polymer shell for iron oxide nanoparticles that can deliver anticancer drugs and enable real-time monitoring of drug release.
According to a report from the Physicist Organization Network on October 30 (Beijing time), recently, a New Scientist from the University of New South Wales, Australia (UNSW) has synthesized a novel type of iron oxide nanoparticles that can not only deliver anticancer drugs to cells but also drugs. Release can be monitored in real time. The researchers said that this is an important advance in the field of nanodiagnostics and treatment. The related papers were published in the recently published American Chemical Society journal ACS Nano.
"This type of iron oxide nanoparticles can track drug delivery and provide the possibility to adapt to individual differences in different patients," said Cyril Boya, associate professor of the School of Chemical Engineering at UNSW. Knowing how the nanoparticle delivered by the anticancer drug is released and its effect on the cells and surrounding tissues, the doctor can adjust the dose to achieve the best therapeutic effect of the drug.
Magnetic iron oxide nanoparticles (IONPs) have been widely studied for a long time, but most of them are used as contrast agents in magnetic resonance imaging (MRI). Until recently, it began to explore their use for drug delivery. At present, only a few studies have described how to load chemotherapeutic drugs on the surfaces of magnetic iron oxide nanoparticles. They have not yet proved effectively that they can deliver drugs to the inside of cells. In this study, we designed a new method to load drugs on the surface of IONPs and demonstrated for the first time that these particles can deliver drugs into the cells.
The UNSW researchers installed IONPs with a well-designed graft polymer shell that gave excellent gel stability in both water and serum. The polymer shell enables reversible adhesion of doxorubicin (DOX), an antitumor drug, through the imine bond, providing a controlled release mechanism for DOX in an acidic environment.
Using a technique called "Fluorescence Lifetime Imaging Microscopy" (FLIM), researchers demonstrated for the first time that IONPs can be easily accepted by two cell lines (MCF-7 breast cancer cells and H1299 lung cancer cells) while being monitored Release of DOX in cells.
"Usually, drug release experiments are only simulated in the laboratory, not in cells. This is very important. With cells we can determine the dynamics of drug release in a real biological environment." Workbench chemistry (traditional chemical experiments that do not use high-end equipment and computer models) can also be performed in cells, and the next step is to enter living applications.†(Reporter Chang Lijun)
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