The working principle and characteristics of the coating machine
A coating machine is a device that wraps a polymer around a tablet core to form a film. That is, the coating machine solution is sprayed onto the surface of the rolling core, and hot air is introduced to evaporate the solvent on the rolling core to form a continuous polymer film on the surface. The formation of droplets, the movement of droplets to the core, the impact, spreading, coalescence of the droplets on the surface of the core, and the drying of the film are all important factors affecting the coating. These require the designer and operator to understand and control. To achieve a high quality coating.
The characteristics of the coating machine: (1) to adjust the release of the drug; (2) to improve the stability of the tablet to prevent oxidative degeneration caused by light or air; (3) to overcome the shortcomings of the tablet is not easy to swallow; 4) Isolation of easily compatible drugs.
Film formation mechanism and influencing factors:
The structure of the film on the core after the coating machine is not uniform, and the appearance is also different. This heterogeneity is caused by insoluble components (such as colorants) that are intentionally added, while the film is not continuously formed during the coating process. Most coating processes are carried out by adhering the polymer solution to the solid core after spraying, and then taking the next spray. This process needs to be repeated several times until the coating is completed. In order to obtain a good coating effect, it is first necessary to understand the formation mechanism of the film.
The following important stages are included throughout the process:
(1) the generation of droplets;
(2) preparation of a coating solution or suspension;
(3) the movement of the mist from the spray gun to the bed;
(4) impact, wetting, spreading and coalescence of the droplets on the surface of the core or on the surface of the particles;
(5) Dry gelation and adhesion to film.
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Label: The working principle and characteristics of the coating machine
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